Multi-Cancer Early Detection in Firefighters

Multi-Cancer Early Detection in Firefighters
March, 2023
Recruitment started
Recruitment status

Firefighters are exposed to a variety of occupational carcinogens, toxic substances, and products of combustion, increasing their risk of developing cancer. The United States' National Institute for Occupational Safety and Health (NIOSH) reported that firefighters have a 9% increase in cancer diagnoses and 14% increase in cancer-related deaths, compared to the general population. Firefighters develop cancer at earlier ages and have significantly higher rates of cancer incidence and mortality compared to the general public, with significant increases in the rates of prostate, lung, oesophageal, gastrointestinal, renal, and brain cancer, as well as melanoma and leukaemia.  

LEVANTIS-0065 (LEV65, part of the study VCC-MCEDFF-001) is an observational prospective cohort research study to explore the performance of the combined free GAGome MCED test in adults actively employed as firefighters in comparison to other MCED tests. This study is a research cooperation between Elypta and the Vincere Cancer Center in Scottsdale, Arizona, wherein plasma and urine specimens are collected from firefighters taking part in Vincere Cancer Center’s First Responder Cancer Screening Program. Elypta expects the results from this study to be of relevance for the wider population, including those who are younger and those who are at high risk of developing cancer.

VCC-MCEDFF-001 is registered at ClinicalTrials.gov (NCT05780957).



Vincere Cancer Center

Scottsdale, Arizona
United States