We are on a path to bring to market the first metabolism-based liquid biopsy for early detection of cancer.
Our MIRAM® kit was developed to enable precise measurements at scale of the most important metabolic biomarkers for this purpose - the GAGome.
We are proud to offer the first standardized, precise, and efficient service for full spectrum glycosaminoglycan quantification using Elypta's MIRAM® Free Glycosaminoglycan Kit.
If you are a researcher interested in using Elypta's MIRAM® Free Glycosaminoglycan Kit in your research, we encourage you to apply for sponsorship to help cover service costs.
Elypta's MIRAM® Free Glycosaminoglycan Kit leverages established state-of-the-art lab methods for glycosaminoglycan (GAG) extraction and detection to deliver high and reliable performance in a standardized and scalable way.
The method relies on an enzymatic digestion assay that depolymerizes GAGs into disaccharides. Disaccharides are subsequently labeled and separated by ultra-high performance liquid chromatography (UHPLC) and detected using electrospray ionization triple-quadrupole mass spectrometry (ESI-MS/MS) through multiple reaction monitoring.
MIRAM® Free Glycosaminoglycan Kits accurately measure the concentration and structural composition of chondroitin sulfate (CS), heparan sulfate (HS), and hyaluronic acid (HA). The measurements can be done in a wide array of research specimens including blood, urine, cell cultures, tissues, and other biofluids. The kit requires only comparatively small sample volumes to produce precise results across the full glycosaminoglycan profile.
MIRAM® Free Glycosaminoglycan Kits are manufactured under contract by Merck KGaA at their Life Science facility in St. Louis, Missouri. The measurements are made at a Good Laboratory Practice-compliant laboratory.
More information about the analytical performance characteristics of the MIRAM® Free Glycosaminoglycan Kit for GAG quantification can be found here: